منابع مشابه
In Vivo Imaging of Schistosomes to Assess Disease Burden Using Positron Emission Tomography (PET)
BACKGROUND Schistosomes are chronic intravascular helminth parasites of humans causing a heavy burden of disease worldwide. Diagnosis of schistosomiasis currently requires the detection of schistosome eggs in the feces and urine of infected individuals. This method unreliably measures disease burden due to poor sensitivity and wide variances in egg shedding. In vivo imaging of schistosome paras...
متن کاملThe use of imaging to detect schistosomes and diagnose schistosomiasis.
Several imaging modalities have been employed to examine schistosomes and monitor schistosome-induced pathology. Ultrasound is a noninvasive imaging method that has long been used in the laboratory and in the field to evaluate pathological changes, notably fibrosis, that arise as a consequence of the host response to schistosome eggs lodging in a variety of tissues. Ultrasonography has been wid...
متن کاملTRP channels in schistosomes
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helm...
متن کاملDesign of Small Animal Computed Tomography Imaging for in vitro and in vivo Studies
Introduction: Mini Computed Tomography (mini-CT) was suggested in biomedical research to investigate tissues and small animals. We present designed and built a mini x-ray computed tomography (mini-CT) for small animals as well as industrial component imaging. Materials and Methods: The system used in this study includes a X-ray tube 20kV to 160kV and a flat pa...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.08-127738